Stephen Hawking, who is the most famous physicist, was born in Britain on January 8^th, 1942. As a child, he was enthusiastic about ____ (design) complicated toys but ____ (fortune), in his twenties, he suffered ____ a disease that was impossible to be cured，____ was a great challenge for him. However, not only was he positive about the misfortunes, and eventually he ____ (defeat) all the obstacles but also he was ____ (absorb) in his research in the universe. In 1988, his best-seller A Brief History of Time ____ (publish), in which he put forward the idea ____ time itself has a beginning, and that it will have ____ end. In____ (conclude), he has made outstanding contributions to the fields of cosmology and quantum gravity.