①细胞无限分裂        ②水分减少，体积变小      ③畸形改变    ④酶活性降低      ⑤色素沉着      ⑥易分散转移    ⑦呼吸速度减慢         ⑧膜透性改变．

已知一组数据的频率为0.35，数据总数为500个，则这组数据的频数为 ____．

-- Do you know the: famous basketball player Kobe has said goodbye to the NBA?

-- Yes. I'm afraid l will           see him on screen.