Stephen Hawking, who is one of the famous physicists, was born in Britain on January 8th, 1942. As a child, he was enthusiastic about ____ (design) complicated toys but ____ (fortune), in his twenties, he suffered____ a disease that was impossible to be cured,____was a great challenge for him. However, he was not only positive about the misfortunes, and eventually he ____ (defeat) all the obstacles but also he was absorbed ____  his research in the universe. In 1988, his best-seller A Brief History of Time ____  (publish), in which he put forward the idea ____ time itself has a beginning, and that it will have ____end. In ____ (conclude), he has made outstanding contributions to the fields of cosmology and quantum gravity.